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. 2012 Jul 2;7(7):e39962. doi: 10.1371/journal.pone.0039962

Figure 3. Sections from sternomastoid muscle in mutated mice.

Figure 3

A and B) In the absence of Jct the overall structure is not visibly altered. A polymer of CASQ fills the jSR and is anchored to the feet-bearing jSR membrane (arrowheads). The size of the transversely cut jSR profiles is slightly smaller than wild type in this image (see detail in Fig. 4C and D). In the absence of Tdn anchors are missing and the visible jSR content quite reduced although still visible. The jSR cisternae are considerably smaller. E and F) In the double mutant, the jSR profiles are very narrow and they seem to be basically empty. In all cases, the jSR-T tubule junctional gap and the rows of feet are unaltered. Colors: white: T-Tubule; yellow: jSR lumen; blue RyRs; Green: anchors. Bar: A–F, 0.1 µm.