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. 2012 Jul 2;7(7):e39962. doi: 10.1371/journal.pone.0039962

Figure 5. Additional structural alterations:

Figure 5

a shift of triads orientation from transverse to longitudinal in fast twitch fibers of EDL and sternomastoid (A, larger arrow) resulting in the development of large jSR plaques carrying multiple rows of feet (D and E). This occurs in fast twitch fibers of Tdn-null fibers, as previously reported, and in the double null mutants. B) The double null mutant fibers show a small number of quite large sacs always located in correspondence of the Z-line (not shown) and filled with a finely granular material similar to the CASQ content of the jSR (star) and some flat SR cisternae (A, B, white arrows, C and detail in F). The flat SR cisternae are separated by small densities that are clearly different from feet (compare D and F, at the same magnification). Bars: A, 0.5 µm; B, 0.5 µm; C, 0.1 µm; D–F, 0.1 µm.