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. 2012 Jul 2;7(7):e38606. doi: 10.1371/journal.pone.0038606

Table 1. Characteristics of studies included in the meta-analysis for an association between XPF-rs1800067, rs1799801, rs2020995, rs744154 SNPs and risk of cancers.

First author, Year Cancer type Country Ethnicity Study type Source of control Cases/Controls MAF of controls P a Powerb Source of DNA Genotyping methods
XPF-rs1800067 (Arg415Gln)
Yu, submitted Head neck USA Caucasian Retrospective HB 1040/1046 0.11 0.485 0.999 Blood SNPlex, PCR-RFLP, Quantitative PCR
Doherty, 2011 Endometrial USA Caucasian Retrospective PB 703/714 0.07 0.184 0.925 Blood, Buccal cells SNPlex, SNaPshot, Quantitative PCR, PCR-RFLP
Gil,2011 Colorectal Poland Caucasian Retrospective HB 133/98 0.08 0.281 0.533 Lymphocytes PCR-RFLP
Krupa, 2011 Larynx Poland Caucasian Retrospective HB 253/253 0.06 0.682 0.876 Lymphocytes PCR-RFLP
Agalliu, 2010 Prostate USA Caucasian Retrospective PB 1221/1219 0.09 0.537 1 Lymphocytes SNPlex
Agalliu, 2010 Prostate USA African American Retrospective PB 144/81 0.02 0.539 0.489 Lymphocytes SNPlex
Rajaraman, 2010 Brain USA Caucasian Retrospective HB 526/471 0.07 0.134 0.809 Blood Quantitative PCR
Abbasi, 2009 Larynx Germany Caucasian Retrospective PB 248/647 0.07 0.163 0.747 Buffy coats Quantitative PCR
Han, 2009 Breast USA Caucasian Prospective PB 1145/1142 0.07 0.527 0.998 Blood BeadArray
Joshi, 2009 Colorectal USA Caucasian Retrospective FB 305/357 – 0.985 0.969 Lymphocytes Quantitative PCR
Chang, 2008 Lung USA Latino Retrospective PB 113/299 0.06 0.331 0.609 Blood, Buccal cells BeadArray
Hung, 2008 Lung Europe Caucasian, Asia Retrospective PB,HB 2520/2619 0.08 0.002 0.995 Blood Pooled
McWilliam, 2008 Pancreatic USA Caucasian Retrospective HB 470/596 0.10 0.003 0.418 Blood SNPstream, Sequencing
Rajaraman, 2008 Breast USA Caucasian Retrospective PB 838/1069 – 0.516 0.995 Blood Quantitative PCR
Smith, 2008 Breast USA Caucasian Retrospective HB 324/406 0.01 0.342 0.826 Blood MassArray
Smith, 2008 Breast USA African American Retrospective HB 53/75 0.06 0.724 0.520 Blood MassArray
Crew, 2007 Breast USA Caucasian Retrospective PB 1018/1065 0.09 0.535 0.999 Lymphocytes FP, Sequenom, Quantitative PCR
Jorgensen, 2007 Breast USA Caucasian Prospective PB 259/275 0.08 0.671 0.920 Buffy coats Quantitative PCR
Huang, 2006 Colorectal USA Mixed Retrospective PB 703/716 0.07 0.313 0.960 Blood Pooled
Mechanic, 2006 Breast USA African American Retrospective PB 757/673 0.02 0.034 0.351 Lymphocytes Quantitative PCR, Sequencing
Mechanic, 2006 Breast USA Caucasian Retrospective PB 1246/1133 0.07 0.113 0.979 Lymphocytes Quantitative PCR, Sequencing
Moreno, 2006 Colorectal Spain Caucasian Retrospective HB 360/323 0.11 0.693 0.969 Blood APEX microarray
Smith, 2003 Breast USA Caucasian Retrospective HB 253/268 0.06 0.439 0.799 Blood PCR-RFLP
XPF-rs1799801 (Ser835Ser)
Doherty, 2011 Endometrial USA Caucasian Retrospective PB 722/727 0.29 0.896 1 Blood, Buccal cells SNPlex, SNaPshot, Quantitative PCR, PCR-RFLP
Roberts, 2011 Breast USA Caucasian Retrospective PB 1063/1913 0.29 0.141 1 Blood, mouthwash samples MassARRAY
Agalliu, 2010 Prostate USA Caucasian Retrospective PB 1259/1243 0.29 0.937 1 Lymphocytes SNPlex
Agalliu, 2010 Prostate USA African American Retrospective PB 145/79 0.16 0.603 0.806 Lymphocytes SNPlex
Wang, 2010 Bladder China Asian Retrospective HB 234/250 0.25 0.412 0.920 Blood PCR-RFLP
Hooker, 2008 Prostate USA African American Retrospective HB 252/301 0.13 0.215 0.812 Blood MassARRAY
Povey, 2007 Melanoma UK Caucasian Retrospective PB 506/441 0.28 0.041 0.856 Blood PCR-RFLP
Garcia-Closas, 2006 Bladder Spain Caucasian Retrospective HB 1091/1019 0.31 0.885 1 leukocytes, mouthwash sample Pooled
Lee, 2005 Breast Korea Asian Retrospective HB 386/336 0.23 0.406 0.970 Blood DASH Hybaid
Matullo, 2005 Bladder UK Caucasian Retrospective HB 204/213 0.32 0.340 0.865 buffy coats Pooled
Shen, 2005 Lung USA Asian Retrospective PB 117/111 0.19 0.231 0.611 Sputum Quantitative PCR
XPF-rs2020955 (Ser662Pro)
Rajaraman, 2010 Brain USA Caucasian Retrospective HB 514/444 0.00 0.917 0.589 Blood Quantitative PCR
Hooker, 2008 Prostate USA African American Retrospective HB 254/301 0.19 0.689 0.972 Blood MassARRAY
Garcia-Closas, 2006 Bladder Spain Caucasian Retrospective HB 1066/1001 0.01 0.859 0.854 leukocytes, mouthwash sample Pooled
Mechanic, 2006 Breast USA African American Retrospective PB 752/674 0.20 0.535 0.999 Lymphocytes Quantitative PCR, Sequencing
Mechanic, 2006 Breast USA Caucasian Retrospective PB 249/250 0.00 0.568 0.399 Lymphocytes Quantitative PCR, Sequencing
XPF-rs744154 (intron)
Wang, 2010 Bladder China Asian Retrospective HB 234/250 0.27 0.004 0.252 Blood PCR-RFLP
Gaudet, 2009 Breast Multicenter Caucasian Retrospective PB,HB 25743/29074 0.28 0.542 1 Pooled Quantitative PCR
Gaudet, 2009 Breast Multicenter African Retrospective PB,HB 651/571 0.25 0.870 1 Pooled Quantitative PCR
Gaudet, 2009 Breast Multicenter Asian Retrospective PB,HB 2700/2104 0.24 0.345 1 Pooled Quantitative PCR

Abbreviation: SNP, single nucleotide polymorphism; HB, Hospital based; PB, Population based; FB, Family based; RFLP, Restriction fragment length polymorphisms.

a

P value for dominant genetic model in the associations with XPF polymorphisms.

b

Statistical power to detect an OR of 1.5 (or 0.67 = 1/1.5).