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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Cancer Res. 2012 Apr 18;10(6):834–844. doi: 10.1158/1541-7786.MCR-12-0025

Figure 2.

Figure 2

Aurora-A ubiquitination is Fbxw7-dependent. (A) NIH3T3 and C5N cells show increased endogenous Aurora-A levels upon treatment with proteasome inhibitor MG132. (B) HCT116 FBXW7 WT and HCT116 FBXW7−/− cells were transfected with HA-ubiquitin. Immunoprecipitation of HA followed by Western blot analysis of Aurora-A showed that ubiquitination of Aurora-A was only seen in the HCT116 FBXW7 WT cells (column 2), and not in HCT116 FBXW7−/− cells (column 4). All results are representative of three independent experiments.