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. 2012 Feb 24;18(1):676–684. doi: 10.2119/molmed.2011.00103

Figure 3.

Figure 3

Effects of BH4, l-arginine (L-arg) and vitamin C (VitC) on oxidative stress in the ischemic gastrocnemius muscle. Muscle was harvested 14 d after the induction of hindlimb ischemia, and supernatants from muscle homogenates were used in these assays. (A) Ni-trotyrosine expression was decreased by all dietary additives, although this decrease was greatest in rats receiving BH4 + l-arginine + vitamin C. (B) The GSH:GSSG ratio was increased in rats receiving BH4 + l-arginine; the addition of vitamin C to this regimen caused an additional increase in this ratio. Data are mean ± sd; n = 5–6. *p < 0.05 versus control, BH4 or l-arginine groups; †p < 0.05 versus BH4 + l-arginine groups.