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. 2012 Jul;181(1):196–210. doi: 10.1016/j.ajpath.2012.03.018

Figure 2.

Figure 2

PCN reduces bacterial burden and down-regulates harmful inflammation in the first 24 hours after infection. Mice are dosed five times daily with PCN or PBS a week before MRSA infection, and were sacrificed at the designated time points. A: The LHs are evaluated for bacterial growth. B–D: BALF is collected on sacrifice. Numbers of neutrophils (B) and mononuclear cells (C) are enumerated by differential count. D: Cell-free supernatant is evaluated for production of cytokines TNF-α, interferon (IFN)-γ, IL-13, IL-6, and MCP-1. Experiments are repeated three times. The mean ± SD of five to six mice per group is shown. *P < 0.05, **P < 0.01, and ***P < 0.001 versus PCN-dosed mice. Black bars/dots, PCN; white bars/dots, PBS.