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. Author manuscript; available in PMC: 2013 Aug 10.
Published in final edited form as: J Mol Biol. 2011 Dec 21;421(2-3):282–295. doi: 10.1016/j.jmb.2011.12.032

Figure 6.

Figure 6

The effects of the Ser-20 substitutions are not a consequence of low levels of co-solvents. (A) Thioflavin-T monitored kinetic experiments of wild type IAPP (black), S20G-IAPP (red) and S20K-IAPP (blue) in the absence of HFIP. (B) An expansion of the first 3 days of panel A. (C) TEM image of the amyloid fibers formed by wild type IAPP. (D) TEM image of the amyloid fibers formed by S20G-IAPP. (E) TEM image of the amyloid fibers formed by S20K-IAPP. Experiments were conducted at 25°C, 20 mM Tris-HCl, pH 7.4, 20 µM IAPP and without stirring or agitation. Scale bars in the TEM images represent 100 nm.