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. 2012 May 19;3(5):535–545. doi: 10.18632/oncotarget.498

Figure 6. Effects of camptothecin (CPT) and topotecan (TPT) on cell cycle proteins and PARP cleavage.

Figure 6

Western blot analysis showing the expression of Cyclin A and cyclin B in the indicated neuroblastoma cell lines treated with CPT or TPT (20nM) for 8-16-24-32hrs. Cleavage of PARP is indicated by the appearance of a 89KDa fragment. The housekeeping gene GAPDH was used as loading control.