Table 3.

Parameters used for bouton Ca^2 + dynamics

Symbol	Description	Value	Reference
F	Faraday’s constant	96487 C mole − 1
R	Real gas constant	8.314 J / K
T	Absolute temperature	293.15 K	Temperature in Perea and Araque [1]
zCa	Calcium valence	2
Abtn	Surface area of bouton	1.24 μm2	[77]
Vbtn	Volume of bouton	0.13 μm3	[77]
ρCa	N-type channel density	3.2 μm − 2	See text
gCa	N-type channel conductance	2.3 pS	[39]
VCa	Reversal potential of Ca2 +  ion	125 mV	Calculated using (4)
νPMCa	Maximum PMCa current	0.4 μA cm − 2	See text
KPMCa	Ca2 +  concentration at which νPMCa is halved	0.1 μM	[27]
νleak	Maximum leak of Ca2 +	2.66 × 10 − 6 ms − 1	See Text
	Resting Intracellular Ca2 +  concentration	0.1 μM	[27]
cext	External Ca2 +  concentration	2 mM	External [Ca2 + ] in Perea and Araque [1]
VmCa	Half-activation voltage of N-type Ca2 +  channel	−17 mV	[40]
kmCa	Slope factor of N-type channel activation	8.4 mV	[40]
c1	Ratio of ER volume to volume of bouton	0.185	Shuai and Jung 2002
ν1	Maximum IP3 receptor flux	30 s − 1	See text
ν2	Ca2 +  leak rate constant	0.055 s − 1	See text
ν3	SERCA maximal pump rate	90 μM s − 1	See text
k3	SERCA dissociation constant	0.1 μM	[86]
d1	IP3 dissociation constant	0.13 μM	Shuai and Jung 2002
d2	Inhibitory Ca2 +  dissociation constant	1.049 μM	Shuai and Jung 2002
d3	IP3 dissociation constant	943.4 nM	Shuai and Jung 2002
d5	Activation Ca2 +  dissociation constant	82.34 nM	Shuai and Jung 2002
a2	Inhibitory Ca2 +  binding constant	0.2 μM s − 1	Shuai and Jung 2002
νg	Maximum production rate of IP3	0.062 μM s − 1	[12]
kg	Glutamate concentration at which vg is halved	0.78 nM	Shuai and Jung 2002
τp	IP3 degradation constant	0.14 s − 1	[87]
p0	Initial IP3 concentration	160 nM	[87]