Table 5.

Parameters used for astrocyte Ca^2 + dynamics

Symbol	Description	Value	Reference
	Maximal IP3R flux	6 s − 1	[30]
rL	Maximal rate of Ca2 +  leak from ER	0.11 s − 1	[30]
c0	Total cell free Ca2 +  concentration	2 μM	[30]
c1,a	Ratio of ER volume to cytosol volume	0.185	[30]
νER	Maximal rate of SERCA uptake	0.9 μM s − 1	[30]
KER	SERCA Ca2 +  affinity	0.1 μM	[30]
d1	IP3 dissociation constant	0.13 μM	[30]
d2	Ca2 +  inactivation dissociation constant	1.049 μM	[30]
d3	IP3 dissociation constant	0.9434 μM	[30]
d5	Ca2 +  activation dissociation constant	0.08234 μM	[30]
a2	IP3R binding rate for Ca2 +  inhibition	2 s − 1	[30]
N	Number of IP3Rs in a cluster	20	[60]
Glutamate-dependent IP3 production
νβ	Maximal rate of IP3 production by PLCbeta	0.5 μM s − 1	[30]
KR	Glutamate affinity of the receptor	1.3 μM	[30]
Kp	Ca2 + /PKC-dependent inhibition factor	10 μM	[30]
	Caaffinity of PKC	0.6 μM	[30]
Glutamate-independent IP3 production
νδ	Maximal rate of IP3 production by PLCδ	0.05 μM s − 1	[30]
	Ca2 +  affinity of PLC	0.1 μM	[30]
	Inhibition constant of PLC activity	1.5 μM	[30]
IP3 degradation
r5pa	Maximal rate of degradation by IP-5P	0.05 s − 1	[30]
ν3 K	Maximal rate of degradation by IP3-3K	2 μM s − 1	[30]
KD	Ca2 +  affinity of IP3-3K	0.7 μM	[30]
K3	IP3 affinity of IP3-3K	1 μM	[30]