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. 1988 Nov 11;16(21):9893–9908. doi: 10.1093/nar/16.21.9893

A survey on intron and exon lengths.

J D Hawkins 1
PMCID: PMC338825  PMID: 3057449

Abstract

The lengths of introns and exons in various parts of genes of vertebrates, insects, plants and fungi are tabulated. Differences between the various groups of organisms are apparent. The results are discussed and support the idea that, generally speaking, introns were present in primitive genomes, though in some cases they may have been inserted into pre-existing genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bingham P. M., Chou T. B., Mims I., Zachar Z. On/off regulation of gene expression at the level of splicing. Trends Genet. 1988 May;4(5):134–138. doi: 10.1016/0168-9525(88)90136-9. [DOI] [PubMed] [Google Scholar]
  2. Blake C. Exons--present from the beginning? Nature. 1983 Dec 8;306(5943):535–537. doi: 10.1038/306535a0. [DOI] [PubMed] [Google Scholar]
  3. Gilbert W. Why genes in pieces? Nature. 1978 Feb 9;271(5645):501–501. doi: 10.1038/271501a0. [DOI] [PubMed] [Google Scholar]
  4. Gillies S. D., Morrison S. L., Oi V. T., Tonegawa S. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell. 1983 Jul;33(3):717–728. doi: 10.1016/0092-8674(83)90014-4. [DOI] [PubMed] [Google Scholar]
  5. Kozak M. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 1987 Oct 26;15(20):8125–8148. doi: 10.1093/nar/15.20.8125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Naora H., Deacon N. J. Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6196–6200. doi: 10.1073/pnas.79.20.6196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Naora H., Miyahara K., Curnow R. N. Origin of noncoding DNA sequences: molecular fossils of genome evolution. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6195–6199. doi: 10.1073/pnas.84.17.6195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Senapathy P. Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2133–2137. doi: 10.1073/pnas.83.7.2133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Traut T. W. Do exons code for structural or functional units in proteins? Proc Natl Acad Sci U S A. 1988 May;85(9):2944–2948. doi: 10.1073/pnas.85.9.2944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Witkowski J. A. The discovery of 'split' genes: a scientific revolution. Trends Biochem Sci. 1988 Mar;13(3):110–113. doi: 10.1016/0968-0004(88)90052-7. [DOI] [PubMed] [Google Scholar]

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