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Mechanism of action of TDRTIs. The RT is represented as a pale green circle with the priming binding site in cyan (P) and the nucleotide binding site in white (N). The RNA template is shown in blue and the (−)strand DNA in purple. The TDRTI triphosphate (strong green) can be used as RT substrate (1) and is incorporated in the nucleic acid (2). The incorporated TDRTI blocks the further DNA synthesis since the enzyme is not able to efficiently translocate (3).
