Skip to main content
. 2012 Mar 23;33(6):1219–1224. doi: 10.1093/carcin/bgs135

Fig. 3.

Fig. 3.

Two hypothetic mechanisms for HBx protein activation in HCC. The protein contains three domains from N- to C-terminal region: an oligomerization domain (OD; aa 21-50); a mitochondria association domain (MT; aa 68-104), which is essential for cell death but not for transactivation function; and a transactivation domain (TAD; aa 132-140). Left: activation by C-truncation (due to integration of 3′-truncated HBX sequence in host genome). Right: activation by neutralization (due to binding of p. R249S to the antiproliferative C-terminal domain of HBx protein encoded by a complete integrated HBX gene).