Fig. 2.

XPA protein levels in lung cancer cell lines are associated with sensitivity to cisplatin. (A) Western blot depicting protein levels of XPA in 11 lung cancer cell lines. (B) XPA expression and sensitivity to cisplatin (IC₅₀) are highly correlated in lung cancer cell lines (r = 0.88; P < 0.001). (C) XPA knockdown sensitizes H2228 and H358 to cisplatin. Transient knockdown was confirmed by western blotting up to 72 h posttransfection. The viability of cells treated with different doses of cisplatin was measured by MTT assay. Each point represents the mean for three wells (mean ± standard error of the mean).