Table 1.

Parameters of the proposed human cardiac muscle cell model. Symbols, physical interpretations, and parameter values.

R	universal gas constant	8.3143 J K−1 mol−1
T	temperature	310K
V	cytoplasmic volume	16404 µm3
F	Faraday constant	96.4867 C/mmol
C	membrane capacitance	185 pF
Vsr	volume of sarcoplastic reticulum	1094 µm3
cNa0	extracellular sodium concentration	140 mM
cK0	extracellular potassium concentration	5.4 mM
cCa0	extracellular calcium concentration	2 mM
$I_{\text{NaK}}^{\text{max}}$	maximum sodium potassium pump current	1.362 pA/pF
$I_{\text{NaCa}}^{\text{max}}$	maximum sodium calcium exchanger current	1000 pA/pF
$I_{\text{leak}}^{\text{max}}$	maximum leakage current	0.08 s−1
$I_{\text{up}}^{\text{max}}$	maximum sarcoplastic reticulum calcium uptake current	0.425 mM/s
$I_{\text{rel}}^{\text{max}}$	maximum sarcoplastic reticulum calcium release current	8.232 mM/s
$C_{\text{Na}}^{\text{max}}$	maximum fast sodium conductance	14.838 nS/pF
$C_{\text{bNa}}^{\text{max}}$	maximum background sodium conductance	0.00029 nS/pF
$C_{\mathrm{K}1}^{\text{max}}$	maximum inward rectifier conductance	5.405 nS/pF
$C_{\text{Kr}}^{\text{max}}$	maximum rapid delayed rectifier conductance	0.0096 nS/pF
$C_{\text{Ks},\text{epi}}^{\text{max}}$	maximum slow delayed rectifier conductance for epicardial cells	0.245 nS/pF
$C_{\text{Ks},\text{endo}}^{\text{max}}$	maximum slow delayed rectifier conductance for endocardial cells	0.245 nS/pF
$C_{\text{Ks},\mathrm{M}}^{\text{max}}$	maximum slow delayed rectifier conductance for M cells	0.062 nS/pF
$C_{\text{pK}}^{\text{max}}$	maximum potassium pump conductance	0.0146 nS/pF
$C_{\mathrm{t}0,\text{epi}}^{\text{max}}$	maximum transient outward conductance for epicardial cells	0.294 nS/pF
$C_{\mathrm{t}0,\text{endo}}^{\text{max}}$	maximum transient outward conductance for endocardial cells	0.073 nS/pF
$C_{\mathrm{t}0,\mathrm{M}}^{\text{max}}$	maximum transient outward conductance for M cells	0.294 nS/pF
$C_{\text{CaL}}^{\text{max}}$	maximum calcium conductance	0.175 mm3/[µFs]
$C_{\text{bCa}}^{\text{max}}$	maximum background calcium conductance	0.000592 nS/pF
$C_{\text{pCa}}^{\text{max}}$	maximum plateau calcium conductance	0.825 nS/pF
cNaCa	half saturation sodium calcium exchanger concentration	87.50 mM
cCaNa	half saturation calcium sodium exchanger concentration	1.38 mM
cNaK	half saturation sodium potassium pump concentration	40.00 mM
cKNa	half saturation potassium sodium pump concentration	1.00 mM
cpCa	half saturation plateau calcium concentration	0.0005 mM
cup	half saturation sarcoplastic reticulum calcium uptake	0.00025 mM
crel	half saturation sarcoplastic reticulum calcium release	0.25 mM
cbuf	half saturation calcium buffer concentration	0.001 mM
ctot	total calcium buffer concentration	0.15 mM
$c_{\text{buf}}^{\text{sr}}$	half saturation sarcoplastic reticulum calcium buffer concentration	0.3 mM
$c_{\text{tot}}^{\text{sr}}$	total sarcoplastic reticulum calcium buffer concentration	10 mM
$k_{\text{NaCa}}^{\text{sat}}$	sodium calcium saturation factor	0.1
pKNa	sodium permeability factor	0.03
γrel	weighting factor	2.0
γNaCa	pump current enhancing factor	2.5
γ	sodium calcium factor	0.35