Figure 4.

Impaired object exploration and contextual fear discrimination in iNR2B^Nes mice. A, Experimental design for novelty exploration. B, C, Total approaches to the objects during training trials and testing reveal iNR2B^Nes mice explored the novel objects significantly less than control mice. D, E, iNR2B^Nes mice did not differ from controls in a one-shock contextual fear conditioning protocol, and did not generalize freezing to a novel context. F, G, iNR2B^Nes mice did not differ from controls in discriminating between two different contexts (experimental design in F). H, I, iNR2B^Nes mice were slower to discriminate two similar contexts than VEH-treated controls (experimental design in H). J, VEH-treated controls could discriminate by the fourth day of training, while iNR2B^Nes could not discriminate until the eighth day of training. *p < 0.05. Data are mean ± SEM.