Table 4.
Coagulation parameters and their prediction of massive transfusion (MT)
| ROC-AUC (95% CI) | Optimum threshold (for best sensitivity and specificity) | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|
| FIBTEM MCF | 0.84 (0.79 to 0.88) | ≤7 mm | 77.5 (66.8 to 86.1) | 74.9 (68.9 to 80.3) |
| FIBTEM A10 | 0.83 (0.78 to 0.87) | ≤4 mm | 63.3 (51.7 to 73.9) | 83.2 (77.8 to 87.7) |
| EXTEM CT | 0.71 (0.66 to 0.76) | ≤72 s | 76.3 (65.2 to 85.3) | 59.4 (52.7 to 65.8) |
| EXTEM CFT | 0.74 (0.68 to 0.79) | ≤147 s | 64.5 (52.7 to 75.1) | 75.1 (69.0 to 80.6) |
| EXTEM MCF | 0.76 (0.71 to 0.81) | ≤52 mm | 67.1 (55.4 to 77.5) | 71.2 (64.8 to 77.0) |
| INTEM CT | 0.71 (0.65 to 0.76) | ≤167 s | 65.3 (53.1 to 76.1) | 75.5 (69.3 to 80.9) |
| INTEM CFT | 0.78 (0.73 to 0.82) | ≤111 s | 75.0 (63.4 to 84.5) | 67.3 (60.7 to 73.4) |
| INTEM MCF | 0.78 (0.73 to 0.83) | ≤51 mm | 61.6 (49.5 to 72.8) | 80.4 (74.5 to 85.3) |
| Platelet count | 0.70 (0.65 to 0.75) | ≤161 × 103/μl | 62.0 (50.4 to 72.7) | 73.8 (67.8 to 79.3) |
| Quick value | 0.87 (0.83 to 0.90) | ≤60% | 84.8 (75.0 to 91.9) | 82.1 (76.6 to 86.8) |
| aPTT | 0.85 (0.81 to 0.89) | ≤35.2 s | 71.6 (59.9 to 81.5) | 87.8 (82.8 to 91.7) |
| Fibrinogen concentration | 0.83 (0.78 to 0.87) | ≤148 mg/dL | 84.2 (74.0 to 91.6) | 68.3 (61.8 to 74.3) |
| Hemoglobin | 0.87 (0.83 to 0.91) | ≤10.1 g/dL | 77.5 (66.8 to 86.1) | 84.5 (79.3 to 88.9) |
| Base deficit | 0.76 (0.76 to 0.86) | ≤6.3 | 69.6 (57.3 to 80.1) | 79.8 (73.3 to 85.3) |
| pH | 0.76 (0.70 to 0.81) | ≤7.276 | 62.3 (49.8 to 73.7) | 80.0 (73.6 to 85.4) |
| Lactate | 0.74 (0.69 to 0.79) | ≤4.18 mmol/L | 54.9 (42.7 to 66.8) | 88.0 (82.9 to 92.0) |
A10, clot amplitude 10 minutes after CT; aPTT, activated partial thromboplastin time; CFT, clot formation time; CI, confidence interval; CT, clotting time; EXTEM, extrinsically activated thromboelastometric test; FIBTEM, extrinsically activated thromboelastometric test with cytochalasin D; INTEM, intrinsically activated thromboelastometric test; MCF, maximum clot firmness; ROC-AUC, area under the receiver operating characteristic curve.