Table 2.
Characteristics of patients in the mild-to-moderate and severe Crohn's disease (CD) groups in 1995
| All | Mild-to-moderate 15-year CD | Severe 15-year CD | p Value* | |
| N | 600 | 279 | 321 | |
| Age, years | 32.6 (26–42) | 36 (28–46) | 31 (24–39) | <0.0001 |
| Female, % | 356 (59) | 158 (57) | 198 (62) | NS |
| Disease duration, years | 5.9 (2.3–10.0) | 9.4 (3.9–15.2) | 5.4 (2.1–10.3) | <0.0001 |
| IBD family history, % | 144 (24) | 67 (24) | 77 (24) | NS |
| Extradigestive manifestations, % | 259 (43) | 113 (40) | 146 (45) | NS |
| Disease location, % | ||||
| L1 | 219 (36) | 107 (38) | 112 (35) | |
| L2 | 171 (28) | 71 (25) | 100 (31) | NS |
| L3 | 209 (35) | 100 (36) | 109 (34) | |
| Upper tract involvement (L4), % | 62 (10) | 28 (10) | 53 (17) | 0.02 |
| Rectal involvement, % | 229 (38) | 90 (32) | 139 (43) | 0.006 |
| Perianal lesions, % | 258 (43) | 122 (44) | 136 (42) | NS |
| Disease behaviour, % | ||||
| B1 | 376 (63) | 152 (54) | 224 (70) | 0.0001 |
| B2 | 82 (14) | 46 (16) | 36 (11) | |
| B3 | 143 (24) | 81 (29) | 61 (19) | |
| Prior immunosuppressants, % | 166 (28) | 65 (23) | 101 (31) | <0.0001 |
| Prior intestinal resection, % | 265 (44) | 152 (54) | 113 (35) | <0.0001 |
| Permanent stoma, % | 34 (6) | 23 (8) | 11 (3) | 0.01 |
| Post-Surgical Handicap Index | 20 (0–34) | 9 (0–25) | 0 (0–18) | <0.0001 |
| Obesity, % | 115 (19) | 57 (20) | 58 (18) | NS |
| High educational level, % | 235 (39) | 126 (45) | 109 (34) | 0.005 |
All quantitative data are given as median (IQR).
*
Comparisons between mild-to-moderate and severe 15-year CD groups.
IBD, inflammatory bowel disease; NS, not significant.