Figure 2.

YM155 exerts minimal effects on cell cycle distribution: Subconfluent PC-3 prostate (A) or EKVX lung (B) cancer cells were treated with or without YM155 for 24 and 48 hours as shown. Cells were then harvested for flow cytometry (FACS) analysis as described in the Materials and Methods. Cell phases (sub-G1, G1, S, G2/M) were labeled on the first sub-panel image, and the percentage of each cell phase distribution in each condition was provided in the Table 2. Similar results from 2008, Hop62, H1650, A549, H3255, MDA-MB-231, LNCaP-LN3, PC-3m, and HCT116 were obtained (not shown).