Table 2.
Cell cycle distribution after YM155 treatment.
| Cell lines | Treatment | Cell cycle distribution (%) | |||
|---|---|---|---|---|---|
|
| |||||
| Sub-G1 | G1 | S | G2/M | ||
| PC3 | DMSO(0.1%),24hrs | 1.09 | 29.95 | 14.91 | 54.42 |
| 10nM YM155,24hrs | 0.91 | 31.13 | 21.04 | 47.74 | |
| 20nM YM155,24hrs | 1.54 | 31.99 | 18.09 | 48.66 | |
| 100nM YM155,24hrs | 6.45 | 15.13 | 18.25 | 58.70 | |
| DMSO(0.1%),48hrs | 0.54 | 42.13 | 12.67 | 45.09 | |
| 5nM YM155,48hrs | 0.85 | 43.35 | 13.38 | 42.64 | |
| 10nM YM155,48hrs | 1.18 | 33.92 | 17.57 | 47.81 | |
| 20nM YM155,48hrs | 4.02 | 18.53 | 19.40 | 57.38 | |
|
| |||||
| EKVX | DMSO(0.1%),24hrs | 1.47 | 60.23 | 7.09 | 31.22 |
| 10nM YM155,24hrs | 8.42 | 51.35 | 10.37 | 29.92 | |
| 20nM YM155,24hrs | 7.73 | 49.61 | 10.42 | 32.19 | |
| 100nM YM155,24hrs | 13.57 | 42.01 | 13.32 | 31.23 | |
| DMSO(0.1%),48hrs | 1. 34 | 61.60 | 9.15 | 27.90 | |
| 5nM YM155,48hrs | 8.20 | 45.08 | 9.53 | 37.19 | |
| 10nM YM155,48hrs | 25.63 | 37.81 | 12.85 | 23.87 | |
| 20nM YM155,48hrs | 41.09 | 31.41 | 10.49 | 17.06 | |