Skip to main content
. 2012 Jun 12;13(7):619–630. doi: 10.1038/embor.2012.78

Table 1. Roles of E3 ligases in chromatin.

E3 Species Substrate Process   Mode Mechanism Recruitment Reference
Bre1 Sc Sp Dm Hs H2B-K123 Txn initiation E Mono Recruitment HMTase 15,16
  Sc Hs H2B-K123 Txn elongation E Mono Decompact FACT? 12,13,18
  Hs H2B-K123 Txn repression E Mono Competition TFIIS 17
MSL2 Hs H2B-134 Txn initiation E Mono Recruitment? HMTase? Bre1? 20
RING1B Dm, Hs H2A (H2A.Z) Txn repression H Mono Masking HTMase, FACT 23,27,28
  Hs H2A Txn repression H Mono Recruitment PRC1 29
  Hs H2A Txn de-repress. H Mono Recruitment ZRF1 29
  Hs H2A Txn repression H Mono Recruitment RYBP? 31
2A-HUB Hs H2A Txn repression H Mono Masking FACT 23
UBR2 Mm H2A Meiotic silenc. H Poly? Masking? FACT? 24
BRCA1 Hs H2A Txn repression H Mono Masking? FACT? 25
SCFPof1 Sp Ams2 Histone levels S Poly Degradation Proteasome 34
Tom1 Sc histones Histone levels S Poly Degradation Proteasome 35
Psh1 Sc Sp Dm Hs Cse4 Histone incorp. E Poly Degradation Proteasome 36, 37
SCFPpa Ds, Hs CID Histone incorp. E Poly Degradation Proteasome 38
Cul4–Ddb1Cdt2 Hs Set8/PR-Set7 Condensation E Poly Degradation Proteasome 42,43,44,45,46
SCFSkp2 Hs MLL Cell cycle S Poly Degradation Proteasome 47
APC/C Hs MLL Cell cycle S Poly Degradation Proteasome 47
SCFFbx4 Hs JMJD2A Cell cycle S Poly Degradation Proteasome 48
Not4 Sc (Hs) Jhd2 (JARID1C) Txn S Poly Degradation Proteasome 49
Cul4–Ddb1Cdt2 Sp Epe1 Boundary H ? ? ? 50
Cul4–Rik1Raf1/2 Sp ? H3K9me H ? ? ? 51,52,53,54,55
Cul4–Ddb1DCAF26 Nc ? H3K9me H ? ? ? 56,57,58,59
Cul2/5–ELC Cr ? H3K9me H ? ? ? 60
Cul4–Ddb1Msi1 At ? H3K27me H ? ? ? 61
Cul4–Ddb1EED Hs ? H3K27me H ? ? ? 62
Msc1 Sp ? HP1 dynamics H ? ? ? 63,64,65,66,67,68
Cul8–Mms1Mms22 Sc Ctf4? Silencing H ? ? ? 69
SCFPof3 Sp Mcl1 (Ctf4)? Silencing H ? ? ? 70
APC/C Sp ? H3K9me H ? ? ? 71

2A-HUB, 2A-histone ubiquitin ligase; APC/C, anaphase promoting complex/cyclosome; At, Arabidopsis thaliana; BRCA1, breast cancer 1; Bre1, brefeldin A sensitivity; Cr, Chlamydomonas reinhardtii; Ctf4, chromosome transmission fidelity; Cul2/4/5/8, Cullin 2/4/5/8; Ddb1, DNA damage-binding protein 1; de-repress., de-repression; Dm, Drosophila melanogaster; E, euchromatin; ELC, elongin E; Epe1, enhancer of position effect 1; H, heterochromatin; Hs, Homo sapiens; incorp., incorporation; Msc1, multi-copy suppressor of Chk1; MSL2, male-specific lethal; Mm, Mus musculus; Mms1, methyl methane sulfonate sensitivity 1; mono, monoubiquitylation; Nc, Neurospora crassa; Not4, negative on TATA; Psh1, Pob3/Spt16/histone associated protein; poly, polyubiquitylation; RING1B, really interesting new gene 1B; S, soluble; Sc, Saccharomyces cerevisiae; SCF, Skp1-Cullin-F-box; Sp, Schizosaccharomyces pombe; Tom1, temperature-dependent organization in mitotic nucleus 1; txn, transcription; UBR2, ubiquitin protein ligase E3 in component n-recognin 2.