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. Author manuscript; available in PMC: 2012 Jul 3.
Published in final edited form as: Cell Rep. 2012 May 10;1(5):424–433. doi: 10.1016/j.celrep.2012.04.001

Figure 2. Highly Expressed Fission Yeast Genes Use a Skewed Codon Content Excluding the AAA and GAA Codons.

Figure 2

(A) Codon bias between G- and A-ending codons for lysine, glutamic acid, and glutamine in genes as a function of mRNA level (upper panel) or ribosome occupancy (lower panel). The data sets used are from a previous study (Lackner et al., 2007).

(B) Hierarchical clustering and heat map analysis of the gene-specific codon usage for each codon (rows) in each S. pombe ORF (column). Clustering was performed based on Z-scores shown in Table S1. Deviations from genome average are shown for each codon according to the color-code key. One main cluster is highlighted and is enriched for the “Translation” GO category that includes highly expressed genes. The codon usage of the rpl26 gene (rotated) exemplifies a skewed codon content for lysine and glutamic acid.