Gross anatomical and histological abnormalities in P20 Nes-Cre/+; Csf1rfl/fl brains. (A) Reduction in brain size along the A/P and the L/R axes, but normal development of the OB in Nes-Cre/+; Csf1rfl/fl mice. (B) Coronal sections stained with hematoxylin and eosin (H&E), showing normal patterning, but a decrease in the forebrain size in Nes-Cre/+; Csf1rfl/fl mice. Note a normal ventricular size and midline crossing of the CC in Nes-Cre/+; Csf1rfl/fl mice. (C) Whole brain weight (left panel) and brain to body weight ratios (right panel). n = 5 mice per group. Ncx, neocortex; STR, striatum; A/P anterio-posterior; L/R, left-right; CC, corpus callosum.