. Author manuscript; available in PMC: 2013 Jul 15.

Published in final edited form as: Dev Biol. 2012 Apr 19;367(2):100–113. doi: 10.1016/j.ydbio.2012.03.026

Table 3.

Brain phenotypes of Csf1^op/op, Csf1r−/− and Nes-Cre/+; Csf1r^fl/fl mice compared to those of wild type mice.

	Mouse Mutant

Phenotype	Csf1^op/op	Csf1r−/−	Nes-Cre/+; Csf1r^fl/fl
Brain size	Reduced	Reduced	Reduced
Brain mass	Increased	Increased	Unchanged
OB atrophy	Absent	Present	Absent
Ventricular size	Unchanged	Increased	Unchanged
CC midline crossing defect	Present (22%^*)	Present (80%^*)	Absent
Cortical thickness	Increased	Reduced	Variable
Cortical NPC proliferation	Increased	Increased	Increased
Excitatory neuronal differentiation	Reduced	Reduced	Variable
Sub-cortical OL differentiation	Reduced	Reduced	Unchanged
Cortical cellular apoptosis	Unchanged	Increased	Increased
Cortical microglia	Reduced	Absent	Unchanged

OB, olfactory bulb; CC, corpus callosum; NPC, neural progenitor cell; OL, oligodendrocyte;

, penetrance