Table 3. Pathways identified by ontological analysis to be over-represented in MSC STAT3C versus MSC AdGFP.

Pathways	Homo sapiens genes	Regulated genes 1.5 fold STAT3C v AdGFP	Expected	P value
Inflammation mediated by chemokine and cytokine signaling pathway	283	23	6.21	1.33E−07
Angiogenesis	191	12	4.19	1.27E−03
Unclassified	17337	362	380.51	6.54E−03
Plasminogen activating cascade	18	3	0.4	7.63E−03
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	35	4	0.77	7.84E−03
Interleukin signaling pathway	161	9	3.53	1.01E−02
Oxidative stress response	60	5	1.32	1.11E−02
Alzheimer disease-presenilin pathway	122	7	2.68	1.94E−02
Blood coagulation	48	4	1.05	2.23E−02
Cytoskeletal regulation by Rho GTPase	98	6	2.15	2.23E−02
Interferon-gamma signaling pathway	29	3	0.64	2.68E−02
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	134	7	2.94	3.01E−02
Ras Pathway	79	5	1.73	3.15E−02
TGF-beta signaling pathway	145	7	3.18	4.29E−02
Threonine biosynthesis	2	1	0.04	4.29E−02
Lysine biosynthesis	2	1	0.04	4.29E−02
Carnitine metabolism	2	1	0.04	4.29E−02
Carnitine and CoA metabolism	2	1	0.04	4.29E−02
FAS signaling pathway	36	3	0.79	4.59E−02
Toll receptor signaling pathway	62	4	1.36	4.91E−02

Pathways identified by ontological analysis to be significantly overrepresented in the differentially regulated genes of the STAT3C MSCs versus AdGFP MSCs analysis.