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. 2012 Jul 3;7(7):e40301. doi: 10.1371/journal.pone.0040301

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Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Expression of TGF-β1 and its receptor were significantly increased in the silicotic model as compared to control. After the intervention of Ac-SDKP, the expression of these proteins decreased significantly. A) The plasma level of TGF-β1 measured by ELISA; C4: control 4w group; S4: silicotic model 4w group; C8: control 8w group; S8: silicotic model 8w group; Ac-post: Ac-SDKP post-treatment group; Ac-pre: Ac-SDKP pre-treatment group; B) The tissue extracts were analyzed by Western blot analysis with antibodies against TGF-β1 and its receptor; C) TGF-β1 expression protein expression measured by Western blot. D) TGF-β receptor type I protein expression measured by Western blot; C) TGF-β receptor type II protein expression measured by Western blot.