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. 2012 Jul 3;10(7):e1001357. doi: 10.1371/journal.pbio.1001357

Figure 5. Rac promotes germline BMP signaling by activating the JNK pathway.

Figure 5

(A–D) BMP signaling in germaria of bamΔ86 females (A,B), and bamΔ86 females with germline expression of Rac1V12 (C,D). (E,G) JNK activity, visualized by puc-lacZ expression, in one GSC of a wild-type germarium and in its descendent Cb, probably as a result of perdurance of β-galactosidase (E), and in all germ cells in a germarium of a female with germline expression of Rac1V12 (G). (F) Kayak-GFP expression in anterior germarium of wild-type female. Inset: white, anti-GFP staining. (H–J) BMP signaling in germaria of a bamΔ86 female with (H) germline expression of Rac1V12 and dominant negative form of Bsk (bskDN), (I) germline expression of constitutively active form of Hep (hepCA), or (J) germline expression of a constitutively active form of Jra (JraCA). (A–J) Arrow, CpC niche; solid line, CpC-GSC interface. (E,F) Dashed outline, individual GSC; solid circle, individual Cb. (A–J) Percentage (%) of total (N) germaria with the specific phenotype displayed in the panel.