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. 2012 Jul 3;6(7):e1721. doi: 10.1371/journal.pntd.0001721

Figure 2. Stimulation of BMDC with rIL-4 prior to LmAg-loading is insufficient to induce protection against leishmaniasis.

Figure 2

BALB/c (A) or CD11ccreIL-4Rα−/lox mice (B) were immunized i.v. with rIL-4-stimulated and L. major antigen-loaded wt BMDC (wt DC/IL-4/LmAg) (▵), a combination of rIL-4 and CpG ODN-activated and L. major antigen-loaded wt BMDC (wt DC/IL-4/CpG/LmAg) (⧫) or CpG ODN-activated and L. major antigen-loaded wt BMDC (wt DC/CpG/LmAg) (□) one week prior to infection with L. major. The footpad swelling was measured weekly. **, p<0.005, ***, p<0.0005 compared to positive control (wt DC/CpG/LmAg) (□). The parasite burden of the infected footpad and the draining popliteal lymph nodes of BALB/c and CD11ccreIL-4Rα−/lox mice was determined six weeks after infection. The results of 10 mice (A) or 5 mice (B) are shown. *, p<0.05, ***, p<0.0005 compared to the respective positive control (wt DC/CpG/LmAg) (□).