Table 3.
Subsequent intervention in patients with post-operative leg pain
| Variable | rhBMP-2 cohort (n = 64) | Control group (n = 40) | P value* | ||
|---|---|---|---|---|---|
| n | % | n | % | ||
| Post-op leg pain | 16 | 25.0 | 5 | 12.5 | 0.140 |
| Cause for leg pain on MRI | 5 | 7.8 | 2 | 5.0 | 0.704 |
| No cause for leg pain on MRI | 11 | 17.1 | 3 | 7.5 | 0.238 |
| Retreatment | |||||
| Overall | 5 | 7.8 | 4 | 10 | 0.730 |
| Revision surgery | 1 | 6.3 | 0 | 0 | 1.000 |
| Nerve root block | 3 | 18.8 | 2 | 40.0 | 1.000 |
| Facet/SI joint anaesthesia | 1 | 6.3 | 3 | 60.0 | 0.028 |
Twenty-five percent (n = 16) of the patients treated with rhBMP-2 and twelve percent (n = 5) of the patients treated without rhBMP-2 complained of severe post-operative leg pain. Overall, 17.2% (n = 11/64) of the patients treated with rhBMP-2 had immediate post-operative leg pain without evidence of nerve root compression on MRI. This compares with 7.5% (n = 3/40) of the patients treated without rhBMP-2 that had immediate post-operative leg pain without MRI evidence of nerve root compression
* P values for categorical variables were generated using Fischer’s exact test