Skip to main content
. Author manuscript; available in PMC: 2013 Jun 5.
Published in final edited form as: Anal Chem. 2012 May 24;84(11):4659–4664. doi: 10.1021/ac301203m

Figure 4.

Figure 4

Measurement of temporal resolution and comparison. (A) Temporal response to a step change from 500 nM to 5 μM acetylcholine using microdialysis coupled directly to ESI-MS/MS without segmented flow. (B) Temporal response for the same experiment with segmented flow and online analysis. Droplets were analyzed at total flow rate of 4 μL/min. (C) Temporal response for same experiment using segmented flow and offline analysis. Droplets were collected in tubing and analyzed offline at infusion rate of 2 μL/min.