Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Pain. 2012 Jun 13;13(7):685–694. doi: 10.1016/j.jpain.2012.04.010

Figure 3.

Figure 3

Confirmation of ERβ inhibition of visceral pain. A: The magnitude of the VMR to graded intensities colorectal distention before and 4 h after s.c. injection of the ERβ agonist WAY200070 (10 mg/kg, n = 12). *** p < 0.001 compared with the baseline. # p < 0.05, ## p < 0.01, ### p < 0.001 compared with baseline for same pressure. B: Fifteen minutes pretreatment with the estrogen receptor antagonist ICI 182,780 (10 nmol) obscured the inhibitory effect of 5 mg/kg DPN (n=11) at 4 h. The inset shows the AUC of four graded intensities distention at baseline and 4 h after 5 mg/kg DPN with or without ICI 182,780. §§ p < 0.01 compared with baseline in same group. For clarification, error bars are only shown in one direction in panel B.