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The cardiac neural crest ablation phenotype. Persistent truncus arteriosus, is observed in 90% of neural crest-ablated embryos while 10% exhibit arterial pole misalignment defects such as double-outlet right ventricle. Abnormal myocardial function, mispatterning of the arch arteries and glandular defects occur in 100% of embryos after cardiac neural crest ablation. (Adapted from Kirby and Hutson, 2010).
