Table VII.
Parameter | 3-week cycle (N = 5) Mean ± SD) | 4-week cycle (N = 16) Mean ± SD) |
---|---|---|
Cmax (mg/dL) | 2184 ± 293 | 2122 ± 425 |
Tmax median (range) (h) | 4.05 (2.67–26.1) | 3.48 (2.6–78.6) |
AUC 0-t (h*mg/dL) | 668,173 ± 118,198 | 852,213 ± 155,334 |
T1/2 (days) (min-max) | 19.6 (4.1) | 33.5 (10.7) |
(16.2–26.7) | (18.3–51.6) | |
CL (mL/kg/day) | 1.97 ± 0.22 | 1.41 ± 0.46 |
Vz (L/kg) | 0.056 ± 0.014 | 0.064 ± 0.015 |