Table 1.

Lipid-related genes for “coronary heart disease” identified through genome-wide association studies

Gene symbol	Gene name	Function
ABCA1	ATP-binding cassette, sub-family A	Cholesterol efflux
APOA5	Apolipoprotein A-V	Plasma triglyceride and HDL
CETP	Cholesteryl ester transfer protein	Transfers cholesteryl esters between lipoproteins
LCAT	Lecithin-cholesterol acyltransferase	Esterifies cholesterol for transport
LDLR	Low-density lipoprotein receptor	LDL-C update
LIPA	Lipase A, lysosomal acid, cholesterol esterase	Catalyze the hydrolysis of cholesteryl esters and triglycerides
LPA	Lipoprotein, Lp(a)	A serine proteinase that inhibits PAI-1
PCSK9	Proprotein convertase subtilisin/kexin type 9	LDL-C homeostasis
SORT1	Sortilin 1	Regulates LDL-C

HDL—high-density lipoprotein; LDL-C—low-density lipoprotein cholesterol; PAI—plasminogen activator inhibitor.