Table 2.
Non-lipid related susceptibility genes for “coronary heart disease” identified through genome-wide association studies
| Gene symbol | Gene name | Function |
|---|---|---|
| ABO | ABO blood group | Glucosyltransferase |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | Zinc-dependent protease |
| ALDH2 | Aldehyde dehydrogenase 2 family | Mitochondrial enzyme in the oxidative pathway |
| ANKS1A | Ankyrin repeat and sterile alpha motif domain containing 1A | A negative regulator of growth factors |
| CDKN2A (CDKN2B) | Cyclin-dependent kinases 2A and 2B | Cell cycle regulators |
| CDKN2B-AS1 (ANRIL) | CDNK2B antisense RNA 1 | Antisense RNA 1 against CDKN2B |
| COL4A1 (COL4A2) | Collagen, type IV, alpha 1 | Collagen |
| CSMD1 | CUB and Sushi multiple domains 1 | Regulator of complement pathway/inflammation |
| CXCL12 | Chemokine (C-X-C motif) ligand 12 | Activate lymphocytes |
| CYP17A1 (CNNM2, NT5C2) | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Drug metabolism and cholesterol/steroid synthesis |
| DNM2 | Dynamin 2 | Endocytosis and cell motility |
| DOCK6 | Dedicator of cytokinesis 6 | Actin cytoskeletal reorganization |
| DTNB | Dystrobrevin, beta | Cytoskeletal protein |
| EDC4 | Enhancer of mRNA decapping 4 | mRNA processing |
| FNDC1 | Fibronectin type III domain containing 1 | G protein signaling |
| GCOM1 | GRINL1A complex locus 1 | Junction protein |
| HFE2 | Hemochromatosis type 2 | Iron metabolism |
| HHIPL1 | HHIP-like 1 | ? |
| HLA, DRB-DQB | Major Histocompatibility Complex, class II, DQ beta1 | Immune response in B lymphocytes, dendritic cells and macrophages |
| HSP90B1 | Heat shock protein 90kDa beta (Grp94), member 1 | Co-chaperone |
| IGSF5 | Immunoglobulin superfamily, member 5 | Cell-cell adhesion |
| KIAA1462 | Uncharacterized protein | ? |
| KLHL29 | Kelch-like 29 | ? |
| LAMC2 | Laminin, gamma 2 | Non-collagen member of basement membranes |
| MIA3 | Melanoma inhibitory activity family, member 3 | Facilitates collagen transport |
| MRAS | Muscle RAS oncogene homolog | Signal transducer in cell growth and differentiation |
| MRPS6 | Mitochondrial ribosomal protein S6 | Ribosomal protein S6 |
| MTAP | Methylthioadenosine phosphorylase | Polyamine metabolism |
| OPRM1 | Opioid receptor, mu 1 | Receptor for opioid peptides and analgesics |
| PDGFD | Platelet-derived growth factor D | Mitogenic factor |
| PHACTR1 | Phosphatase and actin regulator 1 | Regulates protein phosphatase 1 |
| PLEKHO2 | Pleckstrin homology domain containing, family O member 2 | ? |
| PPAP2B | Phosphatidic acid phosphatase type 2B | Synthesis of glycerolipids and phospholipase D signal transduction |
| PPP1R3B | Protein phosphatase 1, regulatory subunit 3B | Regulates glycogen synthesis |
| RASD1 (SMCR3, PEMT) | RAS, dexamethasone-induced 1 | Activator of G-protein signaling |
| RNF130 | Ring finger protein 130 | E3 ubiquitin-protein ligase |
| SH2B3 | SH2B adaptor protein 3 | Negative regulator of cytokine signaling |
| SLC12A9 | Solute carrier family 12, member 9 | Potassium/chloride transporters |
| SLC30A1 | Solute carrier family 30, member 1 | Zinc transporter |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | Regulate gene expression through chromatin modification |
| SMG6 (SRR) | Smg-6 homolog, nonsense mediated mRNA decay factor | Non-sense mediated mRNA decay |
| STK32B | serine/threonine kinase 32B | ? |
| TCF21 | Transcription factor 21 | Transcription factors expressed in epithelial and mesenchymal cells |
| TCF7L2 | Transcription factor 7-like 2 | Transcription factor of Wnt signaling |
| TNIK | TRAF2 and NCK interacting kinase | Cytoskeletal regulation |
| UBE2Z (GIP, ATP5G1, SNF8) | Ubiquitin-conjugating enzyme E2Z | E2 ubiquitin ligase |
| WDR12 | WD repeat domain 12 | Maturation of the large ribosomal subunit. |
| ZC3HC1 | Zinc finger, C3HC-type containing 1 | ? |
| ZFHX3 | Zinc finger homeobox 3 | Transcription factor regulating myogenic and neuronal differentiation |
| ZNF259 | Zinc finger protein 259 | Regulator of neuronal development |