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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Fertil Steril. 2012 Apr 21;98(1):117–125. doi: 10.1016/j.fertnstert.2012.03.030

Figure 2. Genes Involved in Cortisol Synthesis and Action are Altered in Endometriosis.

Figure 2

A–D, Real Time-PCR validation of gene expression in stromal cells from 6 eutopic (E-IUM)and 6 endometriosis (E-OSIS) samples. A, HSD11B1 was significantly upregulated by 7.4-fold and, B, HSD11B2 was significantly downregulated by 0.46-fold in E-OSIS relative to the E-IUM; C, Glucocorticoid Receptor was increased by 2.4-fold in E-OSIS relative to E-IUM; D, Mineralocorticoid Receptor was increased but not significantly. E, Protein expression for HSD11B1, HSD11B2, GR, and β-actin in stromal cells from four normal patients (1–4) and five endometriosis patients (5–9); F–G, Densitometric quantification of HSD11B1 (F), and GR (G) protein levels in eutopic (E-OSIS) versus endometriotic (E-OSIS). Fold Change ± SEM.