Table 1. Monsivais et al.
Microarray gene expression values for the genes involved in prostaglandin synthesis that show abnormal expression in endometriosis relative to the normal endometrium. Also listed are the genes encoding abnormally expressed members of the nuclear receptor superfamily of proteins, the oxidoreductase enzymes, and the hydroxysteroid dehydrogenases. Genes involved in cortisol synthesis, metabolism and action, are altered in endometriosis relative to the normal endometrium.
| PHOSPHOLIPASES | Gene Symbol | E-Osis vs. E-IUM Fold Change | p-value |
|---|---|---|---|
| phospholipase A2, group IIA (platelets, synovial fluid) | PLA2G2A | 59.3 | 2.03E-04 |
| phospholipase A2, group XII | PLA2G12A | 3.78 | 1.21E-02 |
| phospholipase A2, group V | PLA2G5 | 6.92 | 1.23E-03 |
| PROSTAGLANDIN SYNTHASES | |||
| hydroxyprostaglandin dehydrogenase 15-(NAD) | HPGD | −5.28 | 3.03E-03 |
| PROSTAGLANDIN RECEPTORS | |||
| prostaglandin E receptor 2 (subtype EP2) | PTGER2 | 2.81 | 2.76E-02 |
| prostaglandin E receptor 3 (subtype EP3) | PTGER3 | 2.39 | 2.12E-03 |
| prostaglandin E receptor 4 (subtype EP4) | PTGER4 | 3.01 | 4.80E-02 |
| NUCLEAR RECEPTORS | |||
| Thyroid hormone receptor-β | THRB (NR1A2) | 1.77 | 1.09E-02 |
| RAR-related orphan receptor-β | RORB (NR1F2) | −49.18 | 1.70E-06 |
| Farnesoid X receptor | NR1H4 | 3.68 | 2.66E-03 |
| COUP-TF2 | NR2F2 | 2.19 | 3.79E-02 |
| V-erbA-related gene | NR2F6 | −3.89 | 9.13E-05 |
| Estrogen receptor-α | ESR1 (NR3A1) | −4.63 | 1.44E-02 |
| Estrogen receptor-β | ESR2 (NR3A2) | 3.89 | 2.43E-03 |
| Glucocorticoid receptor | NR3C1 | 3.32 | 5.78E-04 |
| Mineralocorticoid receptor | NR3C2 | 10.13 | 6.10E-05 |
| Progesterone receptor | NR3C3 | −13.83 | 6.85E-04 |
| Nerve Growth factor IB | NR4A1 | 4.76 | 4.66E-03 |
| Nuclear receptor related 1 | NR4A2 | 10.34 | 1.17E-04 |
| Neuron-derived orphan receptor 1 | NR4A3 | 3.86 | 1.51E-02 |
| DAX1 | NR0B1 | 2.89 | 4.11E-03 |
| peroxisome proliferative activated receptor, gamma | PPARG | 1.97 | 2.91E-02 |
| OXIDOREDUCTASES | |||
| hydroxysteroid (11-beta) dehydrogenase 1 | HSD11B1 | 7.78 | 3.09E-02 |
| hydroxysteroid (11-beta) dehydrogenase 2 | HSD11B2 | −11.79 | 6.27E-03 |
| ALPHA-KETO REDUCTASES | |||
| Aldo-keto reductase family 1, member A1 (aldehyde reductase) | AKR1A1 | −1.62 | 3.30E-04 |
| aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- alpha)-hydroxysteroid dehydrogenase) | AKR1C1 | 3.20 | 1.33E-03 |
| aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | AKR1C2 | 2.81 | 4.79E-03 |
| aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | AKR1C3 | 3.48 | 3.39E-02 |
| aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | AKR7A2 | −1.54 | 2.81E-02 |