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. Author manuscript; available in PMC: 2013 Jun 29.
Published in final edited form as: Immunity. 2012 Jun 7;36(6):986–1002. doi: 10.1016/j.immuni.2012.05.016

Figure 1. Ly108 expression and function in an acute viral infection.

Figure 1

Ly108 expression on splenic (a) effector (Th1) (CXCR5lo), Tfh (CXCR5hi), and GC Tfh (CXCR5hiPD1hi) CD44hi CD4+ T cells eight days post LCMV infection, and (b) Naïve B cells, plasma cells (CD19+CD138hiIgDlo), and germinal center B cells (CD19+GL7hiFashi) 8 days after LCMV infection. (c-d) CD4+ T cells (c) and B cells (d) from uninfected wild type (WT) and Slamf6−/− mice. (e) Slamf6+/+ and Slamf6−/− mice or (f) Slamf6−/− and SAP−/− mice were infected with LCMV and splenocytes were analyzed for GC B cells 8 days later. (g) WT, Slamf6+/-, and Slamf6−/− mice were infected with LCMV and virus specific serum IgG was measured day 30 post infection. (h) Slamf6−/− and SAP−/− mice were infected with LCMV and virus specific serum IgG was measured day 8 post infection. (a-h) Data are representative of 2 or more independent experiments. N = 4 or more per group. *** P < 0001. Error bars are SEM.