Table 2. Univariate analysis of treatment outcome using 12 genes and clinical factors by log-rank test.

		Disease-free survival		Overall survival
Variables	Group (N)	HR (95% CI)	P -value	HR (95% CI)	P -value
CD73	H (21) vs L (33)	0.77 (0.36–1.64)	0.500	0.71 (0.34–1.50)	0.391
NT5C	H (48) vs L (6)	0.57 (0.13–2.59)	0.322	0.67 (0.20–2.23)	0.509
CDA	H (6) vs L (48)	1.29 (0.40–4.11)	0.630	1.11 (0.37–3.33)	0.842
dCK	H (33) vs L (21)	1.07 (0.51–2.26)	0.965	0.98 (0.46–2.09)	0.852
hCNT3	H (39) vs L (15)	0.73 (0.31–1.70)	0.416	0.69 (0.29–1.63)	0.349
hENT1	H (36) vs L (18)	1.75 (0.80–3.83)	0.202	1.25 (0.53–2.90)	0.621
RRM1	H (11) vs L (43)	1.62 (0.61–4.32)	0.247	1.56 (0.59–4.10)	0.303
RRM2	H (18) vs L (36)	2.85 (1.22–6.62)	0.002	2.69 (1.17–6.20)	0.005
TOP2A	H (26) vs L (28)	1.48 (0.71–3.07)	0.278	1.29 (0.62–2.68)	0.487
TOP2B	H (15) vs L (39)	0.36 (0.17–0.76)	0.023	0.35 (0.16–0.74)	0.024
ABCA3	H (52) vs L (2)	0.41 (0.05–3.53)	0.187	0.57 (0.09–3.61)	0.430
ABCB1	H (30) vs L (24)	0.78 (0.37–1.62)	0.484	0.73 (0.35–1.53)	0.386
Age	⩾60 (13) vs <60 (41)	1.87 (0.75–4.70)	0.099	1.94 (0.77–4.92)	0.090
Sex	Female (26) vs Male (28)	0.63 (0.30–1.32)	0.201	0.69 (0.33–1.43)	0.316
HSCT	No (21) vs Yes (33)	2.13 (0.96–4.69)	0.031	2.09 (0.95–4.60)	0.041
Cytogenetics			0.056
	t(8;21) (24) vs Normal (16)	0.39 (0.16–0.95)	0.012	0.39 (0.16–0.96)	0.022
	Others (14) vs Normal (16)	0.54 (0.22–1.32)	0.165	0.54 (0.22–1.32)	0.182
RI regimen	IDA+BH-AC (35) vs IDA+Ara-C (14)	1.32 (0.59–3.01)	0.512	1.47 (0.66–3.29)	0.373
BM blast, %	⩾50 (26) vs <50 (28)	0.80 (0.39–1.66)	0.540	0.71 (0.34–1.48)	0.347

Abbreviations: BM=bone marrow; CI=confidence interval; H=high expression; HR=hazard ratio; HSCT=haematopoietic stem cell transplantation; L=low expression; RI=remission induction.