Figure A2.

5HT metabolism in a 5HT terminal. Rectangular boxes indicate substrates (see Table A1) and blue ellipses contain the acronyms of enzymes or transporters: V_Ltryp, l-amino acid transporter; DRR, dihydrobiopterin reductase; TPH, tryptophan hydroxylase; AADC, aromatic amino acid decarboxylase; MAT, vesicular monoamine transporter; SERT, 5HT reuptake transporter; auto, 5HT autoreceptors; MAO, monoamine oxidase; ALDH, aldehyde dehydrogenase. Removal means uptake by capillaries or glial cells or diffusion out of the system. In Table A1 various shorter names are used for the 5HT variables in the 5HT terminal and 5HT cell body. The cell body names all start with “r.”