Table A3.

Kinetic parameters (μM, μM/h, /h): 5HT cell body.

Velocity	Parameter	Model value	Literature value	Reference
VAADCrhtp	Aromatic amino acid decarboxylase
	$K_m^{rhtp}$	160	160	Sumi et al. (1990)
	$K_m^{rld}$	130	130	Siaterli et al. (2003)
	Vmax	400		*
VDRR	Dihydropteridine reductase
	$K_m^{rbh2}$	100	4–754	Armarego et al. (1986), Bailey and Ayling (1983)
	$K_m^{\text{NADPH}}$	75	29–770	Firgaira et al. (1981, 1987), Schomburg and Schomburg (2005)
	$V_{max}^f$	5000		*
	$K_m^{rbh4}$	10	1.1–17	Craine et al. (1972), Firgaira et al. (1981)
	$K_m^{\text{NADP}}$	75	29–770	Firgaira et al. (1981, 1987), Schomburg and Schomburg (2005)
	$V_{max}^b$	3		*
VMATrcht	Vesicular monoamine transporter
	$K_m^{rcht}$	0.2	0.123–0.253	Slotkin et al. (1978), Rau et al. (2006)
	$K_m^{rcda}$	3	0.2–10	Sherman and Henry (1983), Near (1986), Volz et al. (2006)
	$V_{max}$	40		*
	kout	0.4		*
VSERT	Serotonin transporter
	Km	0.17	0.05–1	Feldman et al. (1997), Bunin et al. (1998), Daws et al. (2005)
	Vmax	4700		*
VTPH	Tryptophan hydroxylase
	Krtrp	40	40	McKinney et al. (2005)
	Krbh4	20	20	McKinney et al. (2005)
	Vmax	400		*
	Ki (substrate inhibition)	1000	970	McKinney et al. (2005)
VLstryp	Neutral amino acid transporter
	$K_m^{stryp}$	15	15	Kilberg and Haussinger (1992)
	$K_m^{styr}$	64	64	Kilberg and Haussinger (1992)
	$K_m^{sld}$	32	28–102	Hu and Li (2011), Sampaio-Maia et al. (2001)
	Vmax	214		*
CATABOLISM AND DIFFUSION
$V_{\text{rcht}}^{catab}$	Km	95	94–95	Fowler and Ross (1984), Gottowik et al. (1993)
	Vmax	1000		*
$V_{\text{reht}}^{catab}$	Km	95	94–95	Fowler and Ross (1984), Gottowik et al. (1993)
	Vmax	1000		*
$V_{\text{rtryp}}^{catab}$	Km	20		*
	Vmax	74		*
$k_{\text{rtryppool}}^{catab}$		0.8		*
$k_{\text{rhia}}^{catab}$		1	1	Echizen and Freed (1984)
krem		400		*
kleak		14

*See text.