Table A4.

Kinetic parameters (μM, μM/h, /h): DA terminal.

Velocity	Parameter	Model value	Literature value	Reference
VAADC	Aromatic amino acid decarboxylase
	Km	130	130	Siaterli et al. (2003)
	Vmax	10,000		*
VDAT	Dopamine transporter
	Km	0.2	0.2–2	Jones et al. (1995), Schmitz et al. (2003)
	Vmax	8000		*
VDRR	Dihydropteridine reductase
	Kbh2	100	4–754	Armarego et al. (1986), Bailey and Ayling (1983)
	KNADPH	75	29–770	Firgaira et al. (1981, 1987), Schomburg and Schomburg (2005)
	$V_{max}^f$	5000		*
	Kbh4	10	1.1–17	Craine et al. (1972), Firgaira et al. (1981)
	KNADP	75	29–770	Firgaira et al. (1981, 1987), Schomburg and Schomburg (2005)
	$V_{max}^b$	80		*
VMAT	Vesicular monoamine transporter
	Km	3	0.2–10	Sherman and Henry (1983), Near (1986), Volz et al. (2006)
	Vmax	236		*
	kout	0.4		*
VTH	Tyrosine hydroxylase
	Ktyr	46	46	Royo et al. (2004)
	Kbh4	60	13	Royo et al. (2004)
	Vmax	3500		*
	Ki (cda)	110	110	Morgenroth et al. (1976)
	Ki (substrate inhibition)	160	160	Royo et al. (2004); 160 Nakashima et al. (1999)
VLstyr	Neutral amino acid transporter
	$K_m^{styr}$	64	64	Kilberg and Haussinger (1992)
	$K_m^{stryp}$	15	15	Kilberg and Haussinger (1992)
	$K_m^{sld}$	32	28–102	Hu and Li (2011), Sampaio-Maia et al. (2001)
	Vmax	1840		*
tyr↔ Tyrpool
	k1	6		*
	k−1	0.6		*
CATABOLISM AND DIFFUSION
$V_{\text{eda}}^{catab}$	Km	3	3.3	Rivett and Roth (1982)
	Vmax	30		*
$k_{\text{dtyr}}^{catab}$		0.2		*
$k_{\text{dcda}}^{catab}$		10		*
$k_{\text{dhva}}^{catab}$		3.45	3.45	Karoum et al. (1977), Dedek et al. (1979)
$k_{\text{dtyrpool}}^{catab}$		0.2		*
krem		400		*

*See text.