Table A5.

Kinetic parameters (μM, μM/h, /h): LD and DA in the 5HT neuron.

Velocity	Parameter	Model value	Literature value	Reference
VAADC5ld	Aromatic amino acid decarboxylase
	$K_m^{5ld}$	130	130	Siaterli et al. (2003)
	$K_m^{5htp}$	160	160	Sumi et al. (1990)
	Vmax	400		*
VAADCrld	Aromatic amino acid decarboxylase
	$K_m^{rld}$	130	130	Siaterli et al. (2003)
	$K_m^{rhtp}$	160	160	Sumi et al. (1990)
	Vmax	400		*
VLsld	Neutral amino acid transporter
	$K_m^{sld}$	32	28–102	Hu and Li (2011), Sampaio-Maia et al. (2001)
	$K_m^{stryp}$	15	15	Kilberg and Haussinger (1992)
	$K_m^{styr}$	64	64	Kilberg and Haussinger (1992)
	Vmax	1750		*
VMAT5cda	Vesicular monoamine transporter
	$K_m^{5cda}$	0.2	0.2–10	Sherman and Henry (1983), Near (1986), Volz et al. (2006)
	$K_m^{cht}$	3	0.123–0.253	Slotkin et al. (1978), Rau et al. (2006)
	Vmax	40		*
	kout	0.4		*
VMATrcda	Vesicular monoamine transporter
	$K_m^{rcda}$	0.2	0.2–10	Sherman and Henry (1983), Near (1986); Volz et al. (2006)
	$K_m^{rcht}$	3	0.123–0.253	Slotkin et al. (1978), Rau et al. (2006)
	Vmax	196.8		*
	kout	0.4		*
Catabolism
	$k_{5\text{cda}}^{catab}$	10		*
	$k_{\text{rcda}}^{catab}$	10		*