Table 3.
Spearman r- values of significant correlations used for path analysis in figure 4a following Bonferroni correction (p = 0.0002, r = 0.545) between cytokines measured in serum only A), brain only B), or serum and brain C). Letters preceding cytokine/chemokine abbreviations denote brain or serum origin (B- and S- respectively).
| A) Serum-serum | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S-G-CSF | S-GM-CSF | S-IL-1a | S-IL-1b | S-IL-6 | S-IL-10 | S-IL-13 | S-IP-10 | S-KC | S-MCP-1 | S-MIP-1a | S-RANTES | S-TNF-a | |
| S-G-CSF | 1 | NS | NS | NS | 0.5783 | NS | NS | NS | 0.7770 | NS | NS | NS | 0.5714 |
| S-GM-CSF | 1 | NS | NS | 0.6280 | NS | NS | NS | NS | 0.5955 | 0.7032 | NS | 0.6099 | |
| S-IL-1a | 1 | NS | 0.8234 | NS | NS | 0.7102 | 0.6751 | 0.8210 | 0.6568 | 0.6567 | 0.7662 | ||
| S-IL-1b | 1 | NS | NS | NS | NS | NS | NS | NS | NS | NS | |||
| S-IL-6 | 1 | NS | NS | 0.7859 | 0.7821 | 0.9323 | 0.7939 | 0.7308 | 0.9299 | ||||
| S-IL-10 | 1 | NS | NS | NS | NS | NS | NS | NS | |||||
| S-IL-13 | 1 | -0.5489 | NS | NS | NS | -0.5750 | NS | ||||||
| S-IP-10 | 1 | 0.6488 | 0.7977 | 0.7044 | 0.8559 | 0.7810 | |||||||
| S-KC | 1 | 0.7512 | 0.5768 | 0.6777 | 0.7533 | ||||||||
| S-MCP-1 | 1 | 0.8424 | 0.7446 | 0.9212 | |||||||||
| S-MIP-1a | 1 | 0.6943 | 0.8147 | ||||||||||
| S-RANTES | 1 | 0.7083 | |||||||||||
| S-TNF-a | 1 | ||||||||||||
| B) Brain-brain | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B-G-CSF | B-IL-1a | B-IL-1b | B-IL-6 | B-IL-10 | B-IL-13 | B-IP-10 | B-KC | B-MCP-1 | B-MIP-1a | B-RANTES | B-TNF-a | ||
| B-G-CSF | 1 | 0.7201 | NS | 0.7636 | NS | NS | NS | 0.7234 | 0.8208 | 0.7110 | 0.8528 | 0.5456 | |
| B-IL-1a | 1 | NS | 0.6278 | NS | NS | NS | 0.7126 | 0.6524 | 0.7687 | 0.6703 | NS | ||
| B-IL-1b | 1 | NS | NS | 0.6196 | NS | NS | NS | NS | NS | NS | |||
| B-IL-6 | 1 | NS | NS | 0.5760 | 0.6624 | 0.9109 | 0.6258 | 0.6674 | 0.7020 | ||||
| B-IL-10 | 1 | NS | NS | NS | NS | NS | NS | NS | |||||
| B-IL-13 | 1 | NS | NS | NS | NS | NS | NS | ||||||
| B-IP-10 | 1 | 0.7545 | 0.7112 | NS | NS | NS | |||||||
| B-KC | 1 | 0.7524 | 0.5678 | 0.6928 | NS | ||||||||
| B-MCP-1 | 1 | 0.6587 | 0.7337 | 0.6070 | |||||||||
| B-MIP-1a | 1 | 0.8188 | 0.5875 | ||||||||||
| B-RANTES | 1 | NS | |||||||||||
| B-TNF-a | 1 | ||||||||||||
| C) Serum-brain | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S-G-CSF | S-GM-CSF | S-IL-1a | S-IL-1b | S-IL-6 | S-IL-10 | S-IL-13 | S-IP-10 | S-KC | S-MCP-1 | S-MIP-1a | S-RANTES | S-TNF-a | |
| B-G-CSF | 0.913 | NS | NS | NS | NS | NS | NS | NS | 0.695 | NS | NS | NS | NS |
| B-IL-1a | 0.773 | NS | NS | NS | NS | NS | NS | NS | 0.585 | NS | NS | NS | NS |
| B-IL-1b | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |
| B-IL-6 | 0.744 | NS | NS | NS | 0.545 | NS | NS | NS | 0.632 | 0.560 | NS | NS | 0.561 |
| B-IL-10 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |
| B-IL-13 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |
| B-IP-10 | NS | NS | NS | NS | NS | NS | NS | 0.594 | NS | 0.546 | NS | NS | NS |
| B-KC | 0.809 | NS | 0.693 | NS | 0.760 | NS | -0.575 | 0.607 | 0.785 | 0.762 | 0.555 | NS | 0.735 |
| B-MCP-1 | 0.794 | NS | NS | NS | 0.582 | NS | NS | NS | 0.672 | 0.616 | NS | NS | 0.571 |
| B-MIP-1a | 0.664 | NS | NS | NS | NS | 0.567 | NS | NS | NS | NS | NS | NS | NS |
| B-RANTES | 0.832 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |
| B-TNF-a | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |