Table 2.
Global Cognition as a Function of Purpose in Life, 3 Indexes of AD Pathologic Changes, and the Interaction Between Each Pathologic Index and Purpose in Lifea
| Main Effects
|
With Interaction Term
|
|||
|---|---|---|---|---|
| Parameter Estimate (SE) | P Value | Parameter Estimate (SE) | P Value | |
| Model 1 | ||||
| Global AD pathologic changes | −0.601 (0.096) | <.001 | −0.366 (0.135) | .007 |
| Purpose in life | 0.229 (0.123) | .06 | −0.052 (0.165) | .76 |
| Purpose in life × global AD pathologic changes | 0.532 (0.211) | .01 | ||
| Model 2 | ||||
| Amyloid load | −0.082 (0.013) | <.001 | −0.062 (0.020) | .002 |
| Purpose in life | 0.265 (0.124) | .03 | 0.132 (0.161) | .41 |
| Purpose in life × amyloid load | 0.045 (0.035) | .20 | ||
| Model 3 | ||||
| Neurofibrillary tangles | −0.072 (0.008) | <.001 | −0.048 (0.014) | .001 |
| Purpose in life | 0.206 (0.115) | .08 | 0.002 (0.147) | .99 |
| Purpose in life × neurofibrillary tangles | 0.042 (0.019) | .03 | ||
Abbreviation: AD, Alzheimer disease.
a
Derived from linear regression models controlled for age, sex, and educational level.