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. Author manuscript; available in PMC: 2012 Jul 4.
Published in final edited form as: Arch Gen Psychiatry. 2012 May;69(5):499–505. doi: 10.1001/archgenpsychiatry.2011.1487

Table 3.

Examination of Potential Confounders of the Modifying Effect of Purpose In Lifea

Confounder Interaction of Purpose in Life With Global AD Pathologic Changes
Parameter Estimate (SE) P Value
Depressive symptoms (n = 246) 0.647 (0.230) .005
Neuroticism (n = 224) 0.464 (0.282) .10
Social network size (n = 246) 0.566 (0.021) .009
No. of chronic medical conditions (n = 246) 0.540 (0.213) .009
Physical activity (n = 246) 0.584 (0.020) .009
No. of persons with an apolipoprotein ε4 allele (n = 241) 0.459 (0.218) .04
Time to death (n = 246) 0.570 (0.204) .006

Abbreviation: AD, Alzheimer disease.

a

Derived from separate linear regression models adjusted for age, sex, educational level, purpose in life, and AD pathologic characteristics and the interactions of purpose and pathologic characteristics and each of the covariates and pathologic characteristics.