Fig. 1.

Schematic complex in the plasma membrane between rhodopsin (gray; PDB code 1GZM) and the inactive heterotrimeric G protein composed of α_i1, β₁, and γ₂ subunits (light blue/violet, red and yellow respectively; PDB code 1GG2). Gα_i1 N-terminal helix (αN) is shown in brown, while Gα_i1-GTPase and Gα_i1-helical domains (α_i1H) are in light blue and violet respectively. Linker 1 connecting Gα_i1-GTPase to the Gα_i1H is represented in green. Both Gα_i1N and Gγ₂ C-terminal helix (γ₂C) are anchored to the membrane through lipid modification.