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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Biomed Mater. 2012 Mar 29;7(2):024104. doi: 10.1088/1748-6041/7/2/024104

Figure 3. Injection of Photoactivated PEG-HA Hydrogel.

Figure 3

Hillel et al were able to create an in situ crosslinking injectable filler by combining hyaluronic acid (HA) with PEG-diacrylate and the photoinitiator, eosin Y. This mixture of components was injected transdermally (A) and could be massaged into a desired shape (B). The material was then crosslinked by shining an array of light emitting diodes (LEDs) emitting light at a wavelength of 520 nm (C). This light was shown to penetrate up to tissue depths of 4 mm, and a 2 minute exposure time was sufficient to activate the eosin Y and photocrosslink the composite implant. Reprinted with permission from [52].