Table II.
Correlation between clinicopathological parameters and HIF-1α protein expression in osteosarcoma (n=49).
| Parameters | HIF-1α | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| − | 1+ | 2++ | 3+++ | rs | P-value | |
| Agea | 18.5 (11–72) | 1.584 | 0.663 | |||
| Tumor size (cm)b | 8.28±2.53 | 9.91±2.73 | 11.59±0.93 | 12.75±1.20 | 10.189 | <0.001 |
| pTNM stage | 0.310 | 0.030 | ||||
| IIA | 7 | 4 | 0 | 0 | ||
| IIB/III | 15 | 6 | 9 | 8 | ||
| Metastasis | 0.380 | 0.007 | ||||
| No | 18 | 5 | 4 | 3 | ||
| Yes | 4 | 5 | 5 | 5 | ||
| Tumor necrosis rate | −0.464 | 0.001 | ||||
| <90% | 3 | 6 | 6 | 5 | ||
| ≥90% | 19 | 4 | 3 | 3 | ||
P-values were calculated by Spearman’s rank correlation test (n=49);
a
Expressed as median (range), mean2=1.584, P=0.663 (Kruskal-Wallis test);
b
Expressed as mean, F=10.189, P<0.001 (ANOVA test).
HIF-1α, hypoxia-inducible factor 1 α.