Figure 4.

Model of regulation of KCNQ channels function by the Gq signaling pathway. (A) Activation of the PLC by ACh and angiotensin II induces the hydrolysis of PIP₂ to DAG and IP3. (B) Activation of bradykinin and purinergic receptors leads to depletion of PIP₂ by PLC but also its re-synthesis. IP₃ allows releasing Ca²⁺ from endoplasmic reticulum via IP₃R receptor. The released Ca²⁺ can bind to NCS-1 that induces the synthesis of PIP₂ via PI4K or bind to CaM and modulate the channel sensitivity to PIP₂.